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KMID : 0869020080110020072
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Journal of Korean Orthopaedic Research Society
2008 Volume.11 No. 2 p.72 ~ p.83
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Comparison of Bone Formation between Allogenic Periosteum-Derived Mesenchymal Stem Cells and Cultured Osteoblasts Transplanted into Long-Bone Defects of Rabbits
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Kim Hui-Taek
Lee Chang-Bum
Youn Myung-Soo
Lee Jong-Seo
Jun Eun-Sook
Chang Hee-Kyung
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Abstract
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Purpose: To analyze the bone formation between allogenic periosteum-derived mesenchymal stem cells and cultured osteoblasts transplanted into rabbit long-bone defects.
Materials and Methods: Forty white rabbits were grouped according to the material transplanted into their tibial bone defects: stem cells plus agar (group 1); osteoblasts plus agar (group 2); osteoblasts plus gelfoam (group 3). Bone formation was evaluated radiologically, histologically, and using serum osteoblastic markers during 8 weeks following transplantation.
Results: Group 1 and 2 both showed satisfactory bone formation, with group 2 showing thicker and more abundant bone trabeculae than group 1. Rabbits in group 3 showed worse bone formation than group 1 and 2.
Conclusion: These results demonstrate that rabbits implanted with osteoblasts (with agar) showed more satisfactory bone formation than those inserted with stem cells; thus osteoblasts may be useful in the treatment of bone defects.
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KEYWORD
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Rabbit, Osteoblast, Bone formation
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